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KMID : 0616120100410020108
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Korean Journal of Pharmacognosy
2010 Volume.41 No. 2 p.108 ~ p.114
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Anti-inflammatory Effect of MeOH Extract of Cibotium barometz in IFN-g and LPS-stimulated Mouse Peritoneal Macrophage
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Lee Ji-Young
Park Ho-Jun
Lee Yong-Jae
Lee Se-Yeoun
Ko Sung-Hoon
Shin Tae-Yong
Jeon Hoon
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Abstract
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The rhizome of Cibotium barometz has been used for variety of bone disease as a traditional medicine. In the present study, we examined the antioxidant and anti-inflammatory activities of 85% methanol extract of C. barometz. C. barometz exhibited potent scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, superoxide radical and nitric oxide radical. In IFN-g/LPS-stimulated mouse peritoneal macrophage model, C. barometz suppressed nitric oxide production and IL-6 secretion dose-dependently. Moreover, C. barometz showed decreased iNOS and COX-2 expression without notable cytotoxicity. These results suggest that C. barometz may be an useful agent as an antioxidant and anti-inflammatory agent.
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KEYWORD
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Cibotium barometz, antioxidant, anti-inflammatory, nitric oxide
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